Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …

Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …

Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …

In the last ten years, there has been a growing interest regarding the relationship between
gut microbiota, brain, and neurological-associated affections. As multiple preclinical and …

Early-life inflammation increases the risk for depression in later life. Here, we demonstrate
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …

One leading hypothesis suggests that memories are stored in ensembles of neurons (or
'engram cells') and that successful recall involves reactivation of these ensembles. A logical …

Background Pyroptosis mediated by NLRP3 inflammasome plays a critical role in the
pathogenesis of cerebral ischemia-reperfusion (I/R) injury. Mounting evidences have …

Recent findings in human samples and animal models support the involvement of
inflammation in the development of Parkinson's disease. Nevertheless, it is currently …

Traumatic brain injury (TBI) is one of the most common diseases in the central nervous
system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many …

SARS-CoV-2, which causes the Coronavirus Disease 2019 (COVID-19) pandemic, has a
brain neurotropism through binding to the receptor angiotensin-converting enzyme 2 …