Hydrogels have been widely investigated in biomedical fields due to their similar physical
and biochemical properties to the extracellular matrix (ECM). Collagen and hyaluronic acid …

Articular cartilage serves as a low-friction, load-bearing tissue without the support with blood
vessels, lymphatics and nerves, making its repair a big challenge. Transforming growth …

This article reports the first hydrogel with the strength and modulus of cartilage in both
tension and compression, and the first to exhibit cartilage‐equivalent tensile fatigue strength …

Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

Long-read sequencing (LRS) promises to improve the characterization of structural variants
(SVs). We generated LRS data from 3,622 Icelanders and identified a median of 22,636 SVs …

Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate
extracellular matrix production and degradation. In turn, chondrocyte activity is regulated by …

Vascular smooth muscle cells (VSMC s) exhibit phenotypic and functional plasticity in order
to respond to vascular injury. In case of the vessel damage, VSMC s are able to switch from …

Hyaline cartilage is the nonlinear, inhomogeneous, anisotropic, poro-viscoelastic connective
tissue that serves as friction-reducing and load-bearing cushion in synovial joints and is vital …

From an evolutionary perspective keratan sulfate (KS) is the newest glycosaminoglycan
(GAG) but the least understood. KS is a sophisticated molecule with a diverse structure, and …