Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Many forms of cancer have multiple subtypes with different causes and clinical outcomes.
Somatic tumor genome sequences provide a rich new source of data for uncovering these …

Ovarian cancer is the most lethal gynecological malignancy. It is usually diagnosed at a late
stage, with a 5-yr survival rate of< 30%. The majority of ovarian cancer cases are diagnosed …

Fibroblast growth factors (FGFs) and their receptors control a wide range of biological
functions, regulating cellular proliferation, survival, migration and differentiation. Although …

Over the past two decades, the 5-year survival for ovarian cancer patients has substantially
improved owing to more effective surgery and treatment with empirically optimized …

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling pathway
plays a fundamental role in many physiologic processes, including embryogenesis, adult …

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling axis plays
an important role in normal organ, vascular, and skeletal development. Deregulation of …

Germline mutation in either BRCA1 or BRCA2 is associated with an increased risk of
ovarian cancer, particularly the most common invasive histotype—serous carcinoma. In …

Fibroblast growth factor (FGF) signaling regulates cell proliferation, differentiation, survival,
angiogenesis, and wound healing. Compelling evidence for deregulated FGF signaling in …