In recent years, synthetic lethality has been recognized as a solid paradigm for anticancer
therapies. The discovery of a growing number of synthetic lethal targets has led to a …

Simple Summary The DNA damage response pathway plays a critical role in maintaining
genomic integrity. Therefore, inhibition of activation of cell-cycle checkpoints involved in this …

Combination therapy is a fundamental strategy in cancer chemotherapy. It involves
administering two or more anti-cancer agents to increase efficacy and overcome multidrug …

WEE1 is a checkpoint kinase critical for mitotic events, especially in cell maturation and DNA
repair. Most cancer cells' progression and survival are linked with elevated levels of WEE1 …

Breast and gynecological cancers are among the leading causes of death in women
worldwide, illustrating the urgent need for innovative treatment options. We identified MYT1 …

Background Developing novel and effective drugs with less toxicity is urgent for non-small
cell lung cancer (NSCLC) therapy. Xanthotoxol (Xan) is the major natural component of the …

Lung cancer is considered the most commonly diagnosed cancer and one of the leading
causes of death globally. Despite the responses from small-cell lung cancer (SCLC) and …

Silencing of the Apoptosis associated Tyrosine Kinase gene (AATK) has been described in
cancer. In our study, we specifically investigated the epigenetic inactivation of AATK in …

Small cell lung cancer (SCLC) is a recalcitrant malignancy with elusive mechanism of
pathogenesis and dismal prognosis. Over the past decades, platinum-based chemotherapy …

Wee1 is a tyrosine kinase that is highly expressed in several cancer types. Wee1 inhibition
can lead to suppression of tumor cell proliferation and sensitization of cells to the effects of …