Metabolic alterations, a hallmark of cancer, enable tumor cells to adapt to their environment
by modulating glucose, lipid, and amino acid metabolism, which fuels rapid growth and …

Macrophages are the main component of the tumor microenvironment, which are
differentiated from monocytes in the blood and play an important role in cancer …

Background Siglec9 has been identified as an immune checkpoint molecule on tumor-
associated macrophages (TAMs). Nevertheless, the expression profile and clinical …

Oxidative stress, that is, an unbalanced increase in reactive oxygen species (ROS),
contributes to tumor-induced immune suppression and limits the efficacy of immunotherapy …

Cancer immunotherapy has yielded remarkable results across a variety of tumor types.
Nevertheless, the complex and immunosuppressive microenvironment within solid tumors …

Introduction In recent years, immunotherapy has shown significant therapeutic potential in
patients with advanced tumors. However, only a small number of individuals benefit, mainly …

Hepatocellular carcinoma (HCC) represents the most prevalent form of primary liver cancer
and has a high mortality rate. Caspase-8 plays a pivotal role in an array of cellular signaling …

Macrophages are instrumental in maintaining tissue homeostasis, modulating inflammation,
and driving regeneration. The advent of omics techniques has led to the identification of …

Background Hepatocellular carcinoma (HCC) is characterized by a complex pathogenesis
that confers aggressive malignancy, leading to a lack of dependable biomarkers for …

The anti-tumor immune response is greatly hindered by the protumor polarization of tumor-
associated macrophages (TAMs). Cancer-related inflammation plays a central role in TAMs …