Cytomegalovirus latency and reactivation: an intricate interplay with the host immune response
CMV is an ancient herpesvirus that has co-evolved with its host over millions of years. The
236 kbp genome encodes at least 165 genes, four non-coding RNAs and 14 miRNAs. Of the …
236 kbp genome encodes at least 165 genes, four non-coding RNAs and 14 miRNAs. Of the …
The interplay between viral-derived miRNAs and host immunity during infection
MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene
expression during cellular processes. The host-encoded miRNAs are known to modulate the …
expression during cellular processes. The host-encoded miRNAs are known to modulate the …
Targeting CCL5 in inflammation
Introduction: Chemokines play important roles in inflammation and in immune responses.
This article will discuss the current literature on the C–C chemokine ligand 5 (CCL5), and …
This article will discuss the current literature on the C–C chemokine ligand 5 (CCL5), and …
MicroRNAs in infectious diseases: potential diagnostic biomarkers and therapeutic targets
MicroRNAs (miRNAs) are conserved, short, non-coding RNAs that play a crucial role in the
post-transcriptional regulation of gene expression. They have been implicated in the …
post-transcriptional regulation of gene expression. They have been implicated in the …
MicroRNAs as mediators of viral evasion of the immune system
BR Cullen - Nature immunology, 2013 - nature.com
Cellular microRNAs serve key roles in the post-transcriptional regulation of almost every
cellular gene-regulatory pathway, and it therefore is not surprising that viruses have found …
cellular gene-regulatory pathway, and it therefore is not surprising that viruses have found …
Where do we stand after decades of studying human cytomegalovirus?
F Gugliesi, A Coscia, G Griffante, G Galitska… - Microorganisms, 2020 - mdpi.com
Human cytomegalovirus (HCMV), a linear double-stranded DNA betaherpesvirus belonging
to the family of Herpesviridae, is characterized by widespread seroprevalence, ranging …
to the family of Herpesviridae, is characterized by widespread seroprevalence, ranging …
The role of microRNAs in the pathogenesis of herpesvirus infection
D Piedade, JM Azevedo-Pereira - Viruses, 2016 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNAs important in gene regulation. They are
able to regulate mRNA translation through base-pair complementarity. Cellular miRNAs …
able to regulate mRNA translation through base-pair complementarity. Cellular miRNAs …
Human cytomegalovirus in cancer: the mechanism of HCMV-induced carcinogenesis and its therapeutic potential
C Yu, S He, W Zhu, P Ru, X Ge… - Frontiers in Cellular and …, 2023 - frontiersin.org
Cancer is one of the leading causes of death worldwide. Human cytomegalovirus (HCMV), a
well-studied herpesvirus, has been implicated in malignancies derived from breast …
well-studied herpesvirus, has been implicated in malignancies derived from breast …
Viral noncoding RNAs: more surprises
Eukaryotic cells produce several classes of long and small noncoding RNA (ncRNA). Many
DNA and RNA viruses synthesize their own ncRNAs. Like their host counterparts, viral …
DNA and RNA viruses synthesize their own ncRNAs. Like their host counterparts, viral …
The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies?
While the host immune response following primary human cytomegalovirus (HCMV)
infection is generally effective at stopping virus replication and dissemination, virus is never …
infection is generally effective at stopping virus replication and dissemination, virus is never …