Radiopharmaceutical therapy in cancer: clinical advances and challenges

G Sgouros, L Bodei, MR McDevitt… - Nature reviews Drug …, 2020 - nature.com
Radiopharmaceutical therapy (RPT) is emerging as a safe and effective targeted approach
to treating many types of cancer. In RPT, radiation is systemically or locally delivered using …

Exploiting the folate receptor α in oncology

M Scaranti, E Cojocaru, S Banerjee… - Nature reviews clinical …, 2020 - nature.com
Folate receptor α (FRα) came into focus as an anticancer target many decades after the
successful development of drugs targeting intracellular folate metabolism, such as …

The concept of folic acid in health and disease

Y Shulpekova, V Nechaev, S Kardasheva, A Sedova… - Molecules, 2021 - mdpi.com
Folates have a pterine core structure and high metabolic activity due to their ability to accept
electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential …

Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

P Zhang, X Zhou, M He, Y Shang, AL Tetlow… - Nature biomedical …, 2019 - nature.com
The performance of current microfluidic methods for exosome detection is constrained by
boundary conditions, as well as fundamental limits to microscale mass transfer and …

Advances in ovarian cancer therapy

AJ Cortez, P Tudrej, KA Kujawa… - Cancer chemotherapy and …, 2018 - Springer
Epithelial ovarian cancer is typically diagnosed at an advanced stage. Current state-of-the-
art surgery and chemotherapy result in the high incidence of complete remissions; however …

Progress and prospect of immunotherapy for triple-negative breast cancer

C Luo, P Wang, S He, J Zhu, Y Shi, J Wang - Frontiers in Oncology, 2022 - frontiersin.org
Breast cancer is the most commonly diagnosed cancer (estimated 2.3 million new cases in
2020) and the leading cause of cancer death (estimated 685,000 deaths in 2020) in women …

PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy

F Abedi-Gaballu, G Dehghan, M Ghaffari, R Yekta… - Applied materials …, 2018 - Elsevier
Drug delivery systems for cancer chemotherapy are employed to improve the effectiveness
and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have …

Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems

R Bajracharya, JG Song, BR Patil, SH Lee, HM Noh… - Drug Delivery, 2022 - Taylor & Francis
Conventional chemotherapy lacking target selectivity often leads to severe side effects,
limiting the effectiveness of chemotherapy. Therefore, drug delivery systems ensuring both …

Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids

AR Mazo, S Allison-Logan, F Karimi… - Chemical society …, 2020 - pubs.rsc.org
Polypeptides have attracted considerable attention in recent decades due to their inherent
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …

[HTML][HTML] Cancer nanomedicine in preoperative therapeutics: Nanotechnology-enabled neoadjuvant chemotherapy, radiotherapy, immunotherapy, and phototherapy

X Qu, D Zhou, J Lu, D Qin, J Zhou, HJ Liu - Bioactive materials, 2023 - Elsevier
Surgical resection remains a mainstay in the treatment of malignant solid tumors. However,
the use of neoadjuvant treatments, including chemotherapy, radiotherapy, phototherapy …