Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

Mesenchymal stem cells or multipotent stromal cells (MSCs) isolated from the bone marrow
of adult organisms were initially characterized as plastic adherent, fibroblastoid cells with the …

We hypothesized that bone evolved, in part, to enhance the ability of bony vertebrates to
escape danger in the wild. In support of this notion, we show here that a bone-derived signal …

This second edition of the Bone Mechanics Handbook summarizes the current
understanding of bone mechanics with comprehensive coverage of the histology …

Osteocytes are terminally differentiated cells of the osteoblast lineage that have become
embedded in mineralized matrix and may send signals that regulate bone modeling and …

This review compares the biological and physiological function of Sigma receptors [σRs] and
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …

The shape of bone changes as a result of bone remodeling corresponding to physical
circumstances such as mechanical stress. The tissue which receives the loaded mechanical …

Besides the classical ones (support/protection, hematopoiesis, storage for calcium, and
phosphate) multiple roles emerged for bone tissue, definitively making it an organ …

We have previously shown that estrogen withdrawal by gonadotrophin‐releasing hormone
analogs (GnRHa) induces osteocyte death via apoptosis in human bone. Although it is likely …

Since the discovery of its role in the CNS, glutamate, together with its involvement in
signalling at synapses, has been the subject of a vast amount of research. More recently, it …