Genomic information must be faithfully transmitted into two daughter cells during mitosis. To
ensure the transmission process, interphase chromatin is further condensed into mitotic …

The genome is traditionally divided into condensed heterochromatin and open euchromatin.
However, recent findings challenge this binary classification and the notion that chromatin …

Chromatin compaction differences may have a strong impact on accessibility of individual
macromolecules and macromolecular assemblies to their DNA target sites. Estimates based …

Euchromatin is an accessible phase of genetic material containing genes that encode
proteins with increased expression levels. The structure of euchromatin in vitro has been …

In higher eukaryotic cells, a string of nucleosomes, where long genomic DNA is wrapped
around core histones, are rather irregularly folded into a number of condensed chromatin …

Abstract Since Robert Feulgen first stained DNA in the cell, visualizing genome chromatin
has been a central issue in cell biology to uncover how chromatin is organized and behaves …

Corpora amylacea (CA) are polyglucosan aggregated granules that accumulate in the
human body throughout aging. In the cerebrum, CA have been found in proximity to …

A string of nucleosomes, where genomic DNA is wrapped around histones, is organized in
the cell as chromatin. Chromatin in the cell varies greatly, from euchromatin to …

Transmission electron microscopy (TEM) has been essential in defining the structural
organization of the cell due to its ability to image cell structures at molecular resolution …

The genome is not merely organized into a linear string spun around nucleosome but
exhibits a complex hierarchical chromatin structure. These higher order chromatin structures …