Nonlinear Elastic Bottlebrush Polymer Hydrogels Modulate Actomyosin Mediated Protrusion Formation in Mesenchymal Stromal Cells

ML Ohnsorg, KM Mash, A Khang, VV Rao… - Advanced …, 2024 - Wiley Online Library
The nonlinear elasticity of many tissue‐specific extracellular matrices is difficult to
recapitulate without the use of fibrous architectures, which couple strain‐stiffening with …

Three-dimensional analysis of hydrogel-imbedded aortic valve interstitial cell shape and its relation to contractile behavior

A Khang, Q Nguyen, X Feng, DP Howsmon, MS Sacks - Acta biomaterialia, 2023 - Elsevier
Cell-shape is a conglomerate of mechanical, chemical, and biological mechanisms that
reflects the cell biophysical state. In a specific application, we consider aortic valve interstitial …

Estimation of aortic valve interstitial cell-induced 3D remodeling of poly (ethylene glycol) hydrogel environments using an inverse finite element approach

A Khang, J Steinman, R Tuscher, X Feng, MS Sacks - Acta Biomaterialia, 2023 - Elsevier
Aortic valve interstitial cells (AVICs) reside within the leaflet tissues of the aortic valve and
maintain and remodel its extracellular matrix components. Part of this process is a result of …

Hyperglycemia attenuates fibroblast contractility via suppression of TβRII receptor modulated α-smooth muscle actin expression

A Evangelatov, G Georgiev, B Arabadjiev… - Biotechnology & …, 2022 - Taylor & Francis
Nonhealing wounds are a common complication in patients suffering from diabetes with
hyperglycemia being the most deteriorating factor for this serious pathological condition …

An Inverse Modeling Approach to Estimate Three-Dimensional Aortic Valve Interstitial Cell Stress Fiber Force Levels

A Khang, K Meyer, MS Sacks - Journal of …, 2023 - asmedigitalcollection.asme.org
Within the aortic valve (AV) leaflet exists a population of interstitial cells (AVICs) that
maintain the constituent tissues by extracellular matrix (ECM) secretion, degradation, and …