Causes of blindness differ across the globe; in higher-income countries, most blindness
results from the degeneration of specific classes of cells in the retina, including retinal …

Univocal identification of retinal ganglion cells (RGCs) is an essential prerequisite for
studying their degeneration and neuroprotection. Before the advent of phenotypic markers …

Background Inherited retinal degeneration is a leading cause of incurable vision loss in the
developed world. While autologous iPSC mediated photoreceptor cell replacement is …

Background Diabetic retinopathy, a major complication of diabetes mellitus, is a leading
cause of sigh-loss in working age adults. Progressive loss of integrity of the retinal …

The use of human neural stem cells (hNSCs) for clinical cell therapies is limited by the lack
of effective culture substrates to produce hNSCs. Animal-sourced substrates could result in …

End-stage age-related macular degeneration (AMD) and retinitis pigmentosa (RP) are two
major retinal degenerative (RD) conditions that result in irreversible vision loss. Permanent …

Inherited ocular diseases comprise a heterogeneous group of rare and complex diseases,
including inherited retinal diseases (IRDs) and inherited optic neuropathies. Recent success …

Inherited retinal diseases (IRD) are genotypically and phenotypically varied disorders that
lead to progressive degeneration of the outer retina and the retinal pigment epithelium …

Inherited retinal dystrophies (IRDs) are genetic disorders that lead to the bilateral
degeneration of the retina, causing irreversible vision loss. These conditions often manifest …

Inherited retinal diseases (IRDs) represent a genetically and clinically heterogenous group
of diseases that can eventually lead to blindness. Advances in sequencing technologies …