Vision through healthy aging eyes

N Erdinest, N London, I Lavy, Y Morad, N Levinger - Vision, 2021 - mdpi.com
As life expectancy grows, so too will the number of people adversely affected by age.
Although it is acknowledged that many conditions and diseases are associated with age …

Application of collagen I and IV in bioengineering transparent ocular tissues

Y Song, M Overmass, J Fan, C Hodge, G Sutton… - Frontiers in …, 2021 - frontiersin.org
Collagens represent a major group of structural proteins expressed in different tissues and
display distinct and variable properties. Whilst collagens are non-transparent in the skin …

Mesenchymal stem cells and exosomes: A novel therapeutic approach for corneal diseases

B Bhujel, SH Oh, CM Kim, YJ Yoon, YJ Kim… - International Journal of …, 2023 - mdpi.com
The cornea, with its delicate structure, is vulnerable to damage from physical, chemical, and
genetic factors. Corneal transplantation, including penetrating and lamellar keratoplasties …

Early and late-onset cell migration from peripheral corneal endothelium

A Miron, S Ní Dhubhghaill, V Kocaba, MJ Jager… - PLoS …, 2023 - journals.plos.org
In this study we describe peripheral corneal endothelial cell migration in vitro in the absence
and presence of a ROCK-inhibitor. For this study, 21 corneal endothelial graft rims, with …

Application of mesenchymal stem cells in corneal regeneration

M Ghiasi, K Jadidi, M Hashemi, H Zare, A Salimi… - Tissue and Cell, 2021 - Elsevier
Due to delicate its structure, the cornea is susceptible to physical, chemical, and genetic
damages. Corneal transplantation is the main treatment for serious corneal damage, but it …

Directed differentiation of human pluripotent stem cells towards corneal endothelial-like cells under defined conditions

P Grönroos, T Ilmarinen, H Skottman - Cells, 2021 - mdpi.com
The most crucial function of corneal endothelial cells (CEnCs) is to maintain optical
transparency by transporting excess fluid out of stroma. Unfortunately, CEnCs are not able to …

Investigating the Role of TGF-β Signaling Pathways in Human Corneal Endothelial Cell Primary Culture

I Aouimeur, T Sagnial, L Coulomb, C Maurin, J Thomas… - Cells, 2023 - mdpi.com
Corneal endothelial diseases are the leading cause of corneal transplantation. The global
shortage of donor corneas has resulted in the investigation of alternative methods, such as …

Use of biomaterials in corneal endothelial repair

NA Hussain, FC Figueiredo… - Therapeutic Advances …, 2021 - journals.sagepub.com
Human corneal endothelium (HCE) is a single layer of hexagonal cells that lines the
posterior surface of the cornea. It forms the barrier that separates the aqueous humor from …

[HTML][HTML] BCAR1 plays critical roles in the formation and immunoevasion of invasive circulating tumor cells in lung adenocarcinoma

CG Mao, S Jiang, X Wang, SL Tao, B Jiang… - … Journal of Biological …, 2021 - ncbi.nlm.nih.gov
Background: We investigated the roles of breast cancer anti-estrogen resistance 1
(BCAR1/p130Cas) in the formation and immunoevasion of invasive circulating tumor cells …

[HTML][HTML] Effect of mechanical stretching and substrate stiffness on the morphology, cytoskeleton and nuclear shape of corneal endothelial cells

R Du, D Li, Y Huang, H Xiao, J Xue, J Ji, Y Feng… - Medicine in Novel …, 2022 - Elsevier
Due to the limited capacity of corneal endothelial cells (CECs) division, corneal endothelial
diseases have become a great challenge. The cornea is subjected to various mechanical …