Lung cancer is the primary cause of mortality in the United States and around the globe.
Therapeutic options for lung cancer treatment include surgery, radiation therapy …

Oncolytic viruses (OVs) have attracted growing awareness in the twenty-first century, as they
are generally considered to have direct oncolysis and cancer immune effects. With the …

Oncolytic viruses offer an in situ vaccination approach to activate tumor-specific T cell
responses. However, the upregulation of PD-L1 expression on tumor cells and immune cells …

Cancer vaccines and oncolytic immunotherapy are promising treatment strategies with
potential to provide greater clinical benefit to patients with advanced-stage cancer. In …

Cytokines are molecular messengers that allow the cells of the immune system to
communicate with one another to generate a coordinated, robust, but self-limited response …

While checkpoint blockade immunotherapies have widespread success, they rely on a
responsive immune infiltrate; as such, treatments enhancing immune infiltration and …

The immune status of the tumor microenvironment is a key indicator in determining the
antitumor effectiveness of immunotherapies. Data support the role of activation and …

The efficacy and safety of biological molecules in cancer therapy, such as peptides and
small interfering RNAs (siRNAs), could be markedly increased if high concentrations could …

Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. They kill
infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells …

Despite the success of the WHO-led smallpox eradication programme a quarter of a century
ago, there remains considerable fear that variola virus, or other related pathogenic …