The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

The chromatin remodeler SMARCA4/BRG1 is a key epigenetic regulator with diverse roles
in coordinating the molecular programs that underlie brain tumour development. BRG1 …

Background Aberrant changes in epigenetic mechanisms such as histone modifications play
an important role in cancer progression. PRMT1 which triggers asymmetric dimethylation of …

Triple-negative breast cancer (TNBC) is the most challenging breast cancer subtype for its
high rates of relapse, great metastatic potential, and short overall survival. How cancer cells …

Background SMARCA4, the essential ATPase subunit of SWI/SNF chromatin remodeling
complex, regulates transcription through the control of chromatin structure and is …

Diffuse midline gliomas are uniformly fatal pediatric central nervous system cancers that are
refractory to standard-of-care therapeutic modalities. The primary genetic drivers are a set of …

The polybromo-associated PBAF (SWI/SNF) chromatin remodeling complex, which includes
PBRM1, ARID2, and BRD7, regulates cell differentiation and genomic integrity. MUC1-C is …

Patients with diffuse midline gliomas that are H3K27 altered (DMG) display a dismal
prognosis. However, the molecular mechanisms underlying DMG tumorigenesis remain …

Abstract The Brg/Brahma-associated factor (BAF, mSWI/SNF) chromatin remodeling
complex is of importance in development and has been linked to prostate oncogenesis. The …

Genes encoding subunits of SWItch/Sucrose Non-Fermenting (SWI/SNF) chromatin
remodeling complexes are collectively mutated in 20% of all human cancers, among which …