Neurons of the mammalian central nervous system fail to regenerate. Substantial progress
has been made toward identifying the cellular and molecular mechanisms that underlie …

Wallerian degeneration is a widespread mechanism of programmed axon degeneration. In
the three decades since the discovery of the Wallerian degeneration slow (Wld S) mouse …

Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

The nicotinamide adenine dinucleotide hydrolase (NADase) sterile alpha toll/interleukin
receptor motif containing-1 (SARM1) acts as a central executioner of programmed axon …

Axonal degeneration is an early and ongoing event that causes disability and disease
progression in many neurodegenerative disorders of the peripheral and central nervous …

Axons are electrically excitable, cable-like neuronal processes that relay information
between neurons within the nervous system and between neurons and peripheral target …

Summary SARM1 is an NAD (P) glycohydrolase and TLR adapter with an essential,
prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD …

The NADase SARM1 is a central switch in injury-activated axon degeneration, an early
hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo …

Background In response to injury, neurons activate a program of organized axon self-
destruction initiated by the NAD+ hydrolase, SARM1. In healthy neurons SARM1 is …

Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite that is reported to
decline in concentration in tissues of aged animals. Strategies to increase NAD+ availability …