A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

Retroviruses are obligate intracellular parasites that must integrate a copy of the viral
genome into the host DNA. The integration reaction is performed by the viral enzyme …

The field of retroviral integration research has a long history that started with the provirus
hypothesis and subsequent discoveries of the retroviral reverse transcriptase and integrase …

The retroviral protein Integrase (IN) catalyzes concerted integration of viral DNA into host
chromatin to establish a permanent infection in the target cell. We learned a great deal about …

Murine leukemia viruses (MLVs) have long been used as a research model to further our
understanding of retroviruses. These simple gammaretroviruses have been studied …

Murine leukemia virus (MLV) integrase (IN) lacking the C-terminal tail peptide (TP) loses its
interaction with the host bromodomain and extraterminal (BET) proteins and displays …

The Moloney murine leukemia virus (MLV) is a prototype gammaretrovirus requiring nuclear
disassembly before DNA integration. In the nucleus, integration site selection towards …

Retroviral integrase (IN) proteins catalyze the permanent integration of the viral genome into
host DNA. They can productively recruit cellular proteins, and the human Bromodomain and …

Integration of the reverse-transcribed viral cDNA into the host's genome is a critical step in
the lifecycle of all retroviruses. Retrovirus integration is carried out by integrase (IN), a virus …

Retroviral vectors show long‐term gene expression in gene therapy through the integration
of transgenes into the human cell genome. Murine leukemia virus (MLV), a well‐studied …