The prevalence of cerebrovascular disease increases with age, placing the elderly at a
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …

As a complex multicellular structure of the vascular system at the central nervous system
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …

The blood-brain barrier (BBB) plays a key role in maintaining the specialized
microenvironment of the central nervous system (CNS), and enabling communication with …

There are currently various concerns regarding certain environmental toxins and the
possible impact they can have on developmental diseases. Glyphosate (Gly) is the most …

Over two-thirds of individuals aged 65 and older are obese or overweight in the United
States. Epidemiological data show an association between the degree of adiposity and …

Background: The blood–brain barrier acts as a highly regulated interface; its dysfunction
may exacerbate, and perhaps initiate, neurological and neuropsychiatric disorders …

Background Pericytes and endothelial cells are critical cellular components of the blood-
brain barrier (BBB) and play an important role in neuroinflammation. To date, the majority of …

Purpose It has been supposed that cardiac toxicity of doxorubicin is due to its production of
free radicals and inflammatory cytokines. Dapsone, an antibiotic drug which is the principal …

Abstract Zonula occludens-1 (ZO-1) is essential to the proper assembly of interendothelial
junction complexes that control blood–brain barrier (BBB) integrity. The goal of the current …

Abstract Aim/Background: This research aims to prevent progression from mild cognitive
impairment (MCI) to Alzheimer's disease. A Japanese study of leprosy patients revealed that …