Advancing antimicrobial strategies for managing oral biofilm infections

Y Jiao, FR Tay, L Niu, J Chen - International journal of oral science, 2019 - nature.com
Effective control of oral biofilm infectious diseases represents a major global challenge.
Microorganisms in biofilms exhibit increased drug tolerance compared with planktonic cells …

Biotechnological insights on the expression and production of antimicrobial peptides in plants

B Shanmugaraj, CJI Bulaon, A Malla, W Phoolcharoen - Molecules, 2021 - mdpi.com
The emergence of drug-resistant pathogens poses a serious critical threat to global public
health and requires immediate action. Antimicrobial peptides (AMPs) are a class of short …

Expression systems for heterologous production of antimicrobial peptides

NS Parachin, KC Mulder, AAB Viana, SC Dias… - Peptides, 2012 - Elsevier
Antimicrobial peptides (AMPs) consist of molecules that act on the defense systems of
numerous organisms toward multiple pathogens such as bacteria, fungi, parasites and …

Computational tools for exploring sequence databases as a resource for antimicrobial peptides

WF Porto, AS Pires, OL Franco - Biotechnology advances, 2017 - Elsevier
Data mining has been recognized by many researchers as a hot topic in different areas. In
the post-genomic era, the growing number of sequences deposited in databases has been …

GASA proteins: Review of their functions in plant environmental stress tolerance

MT Bouteraa, W Ben Romdhane, N Baazaoui… - Plants, 2023 - mdpi.com
Gibberellic acid-stimulated Arabidopsis (GASA) gene family is a class of functional cysteine-
rich proteins characterized by an N-terminal signal peptide and a C-terminal-conserved …

[HTML][HTML] Selective amino acid substitution reduces cytotoxicity of the antimicrobial peptide mastoparan

LN Irazazabal, WF Porto, SM Ribeiro, S Casale… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The emergence of antibiotic-resistant clinical isolates and the decreased rate of
development of new antibiotics are a constant threat to human health. In this context, the …

CS-AMPPred: an updated SVM model for antimicrobial activity prediction in cysteine-stabilized peptides

WF Porto, ÁS Pires, OL Franco - PLoS One, 2012 - journals.plos.org
The antimicrobial peptides (AMP) have been proposed as an alternative to control resistant
pathogens. However, due to multifunctional properties of several AMP classes, until now …

Targeting methicillin-resistant Staphylococcus aureus with short salt-resistant synthetic peptides

MF Mohamed, MI Hamed, A Panitch… - Antimicrobial agents …, 2014 - Am Soc Microbiol
The seriousness of microbial resistance combined with the lack of new antimicrobials has
increased interest in the development of antimicrobial peptides (AMPs) as novel …

Selective antibacterial activity of the cationic peptide PaDBS1R6 against Gram-negative bacteria

ICM Fensterseifer, MR Felicio, ESF Alves… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Infections caused by Gram-negative bacteria, Escherichia coli and Pseudomonas
aeruginosa foremost among them, constitute a major worldwide health problem …

Direct and indirect antimicrobial activities of neuropeptides and their therapeutic potential

D Augustyniak, J Nowak… - Current Protein and …, 2012 - ingentaconnect.com
As global resistance to conventional antibiotics rises we need to develop new strategies to
develop future novel therapeutics. In our quest to design novel anti-infectives and …