Ribosome assembly is a complex process reliant on the coordination of trans-acting
enzymes to produce functional ribosomal subunits and secure the translational capacity of …

Many physiological functions of helicases are dependent on their ability to unwind nucleic
acid duplexes in an ATP-dependent fashion. Determining the kinetic frameworks of these …

Even though the RNAs contained in the small (40S) and large (60S) ribosomal subunits are
cotranscribed, their assembly proceeds largely separately, involving entirely distinct …

Argonaute (AGO) proteins are key nuclease effectors of RNAi [1]. Although purified AGOs
can mediate a single round of target RNA cleavage in vitro, accessory factors are required …

The DEAD-box RNA helicase DDX3X promotes translation initiation and associates with
stress granules. A range of diverse viruses produce proteins that target DDX3X, including …

RNA helicases are the largest class of enzymes in eukaryotic RNA metabolism. In cells,
protein cofactors regulate RNA helicase functions and impact biochemical helicase …

Histidine protein kinases (HKs) are prevalent prokaryotic sensor kinases that are central to
phosphotransfer in two-component signal transduction systems, regulating phosphorylation …

Despite the highly conserved helicase core, individual DEAD-box proteins are specialized in
diverse RNA metabolic processes. One mechanism that determines DEAD-box protein …

RNA helicases comprise a large family of ubiquitously expressed enzymes that remodel
RNA structures and RNA-protein complexes in an NTP-dependent manner. These proteins …

In eukaryotes, there are highly coupled mechanisms that require RNA-binding proteins to
facilitate gene expression. Proper RNA structure and ribonucleoprotein (RNP) complex …