Cancers can be categorized into two groups: those whose frequency increases with age,
and those resulting from errors during mammalian development. The first group is linked to …

The trophoblast cells that take part in placenta formation are characterized by different
modes of multiplication of their genome that largely designates their eu‐or aneuploidy level …

The challenging task of mitotic cell divisions is to generate two genetically identical daughter
cells from a single precursor cell. To accomplish this task, a complex regulatory network …

The study of proliferation regulation in human pluripotent stem cells is crucial to gain insights
into understanding the physiology of these cells. However, redox regulation of the …

Ex ovo omnia—all animals come from eggs—this statement made in 1651 by the English
physician William Harvey marks a seminal break with the doctrine that all essential …

Geminin is a protein involved in both DNA replication and cell fate acquisition. Although it is
essential for mammalian preimplantation development, its role remains unclear. In one …

The mechanism that duplicates the nuclear genome during the trillions of cell divisions
required to develop from zygote to adult is the same throughout the eukarya, but the …

Objectives. Human papillomaviruses (HPV) are associated with cell cycle arrest. This study
focused on antioxidant selenomethionine (SeMet) inhibition of HPV‐mediated necrosis. The …

Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks
expression of estrogen, progesterone, and human epidermal growth factor 2 receptors …

Nothing is more fundamental to mammalian development than the ability to accurately
reproduce its genome once—but only once—each time a cell divides. In fact, the basic …