Vancomycin is widely used in pediatric patients, however, large inter-and intraindividual
variability are observed in vancomycin pharmacokinetics, affecting proper therapeutic …

Background Vancomycin is commonly used to treat gram-positive bacterial infections in the
paediatric population, but dosing can be challenging. Population pharmacokinetic (popPK) …

The revised vancomycin guidelines recommend implementing AUC24-based therapeutic
drug monitoring (TDM) using Bayesian methods in both adults and paediatrics. The …

In this counterpoint we critically appraise the evidence supporting therapeutic drug
monitoring based on the vancomycin 24-hour area under the concentration-time curve …

Therapeutic drug monitoring (TDM) has been a common practice to optimize efficacy and
safety of vancomycin. While vancomycin trough-only TDM has widely been integrated into …

Background The pharmacokinetics of vancomycin, a drug used for the treatment of
methicillin-resistant Staphylococcus aureus (MRSA), varies between paediatric and adult …

Antibiotics are among the most utilized drugs in pediatrics. Nonetheless, there is a lack in
pharmacokinetics information for this population, and dosing criteria may vary between …

In Greek mythology, the Titans piled Mount Pelion and Mount Ossa upon Olympus to scale
the dwellings of the Gods but were overwhelmed by Zeus.“Heaping Pelion upon Ossa” thus …

Background Vancomycin is commonly used to treat methicillin-resistant staphylococcal
infections in neonates. Consensus on its ideal dosing in neonates has not been achieved …

Optimal vancomycin exposure is important to minimize treatment failure of methicillin-
resistant Staphylococcus aureus (MRSA) bacteremia. We aimed to analyze the impact of …