There is currently great interest in developing mucosal vaccines against a variety of
microbial pathogens. Mucosally induced tolerance also seems to be a promising form of …

Currently, aluminum salts and MF59 are the only vaccine adjuvants approved for human
use. With the development of new-generation vaccines (including recombinant subunit and …

BACKGROUND: Subcutaneous allergen-specific immunotherapy frequently causes allergic
side effects and requires 30 to 80 injections over 3 to 5 years. OBJECTIVE: We sought to …

New generation vaccines, particularly those based on recombinant proteins and DNA, are
likely to be less reactogenic than traditional vaccines, but are also less immunogenic …

New generation vaccines, particularly those based on recombinant proteins and DNA, are
likely to be less reactogenic than traditional vaccines but are also less immunogenic …

Next generation veterinary vaccines are going to mainly comprise of either subunit or
inactivated bacteria/viruses. These vaccines would require optimal adjuvants and delivery …

Adjuvants can be broadly divided into two groups, based on their principal mechanisms of
action: vaccine delivery systems and immunostimulatory adjuvants. Vaccine delivery …

Mucosal tissues are major sites of HIV entry and initial infection. Thus, the induction of a
mucosal cytotoxic T lymphocyte (CTL) response is an important feature for an effective HIV …

Microparticles have been effectively used for many years as delivery systems for drugs and
therapeutic proteins. Their application to the delivery of vaccines is not as extensive, but is …

Ty virus-like particles consist of a single protein species that can be produced in yeast.
Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) …