Evolution of ageing as a tangle of trade-offs: energy versus function

AA Maklakov, T Chapman - Proceedings of the Royal …, 2019 - royalsocietypublishing.org
Despite tremendous progress in recent years, our understanding of the evolution of ageing
is still incomplete. A dominant paradigm maintains that ageing evolves due to the competing …

The Williams' legacy: A critical reappraisal of his nine predictions about the evolution of senescence

JM Gaillard, JF Lemaître - Evolution, 2017 - academic.oup.com
Williams' evolutionary theory of senescence based on antagonistic pleiotropy has become a
landmark in evolutionary biology, and more recently in biogerontology and evolutionary …

[HTML][HTML] The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

K Yen, HH Mehta, SJ Kim, YH Lue, J Hoang… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Humanin is a member of a new family of peptides that are encoded by short open reading
frames within the mitochondrial genome. It is conserved in animals and is both …

Pleiotropy, epistasis and the genetic architecture of quantitative traits

TFC Mackay, RRH Anholt - Nature Reviews Genetics, 2024 - nature.com
Pleiotropy (whereby one genetic polymorphism affects multiple traits) and epistasis
(whereby non-linear interactions between genetic polymorphisms affect the same trait) are …

[HTML][HTML] Caenorhabditis elegans as an in vivo model for the identification of natural antioxidants with anti-aging actions

Y Lin, C Lin, Y Cao, Y Chen - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Natural antioxidants have recently emerged as a highly exciting and significant topic in anti-
aging research. Diverse organism models present a viable protocol for future research …

Lifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite

S Séité, MC Harrison, D Sillam-Dussès… - Communications …, 2022 - nature.com
Kings and queens of eusocial termites can live for decades, while queens sustain a nearly
maximal fertility. To investigate the molecular mechanisms underlying their long lifespan, we …

[HTML][HTML] Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline

L Slade, T Etheridge, NJ Szewczyk - Ageing Research Reviews, 2024 - Elsevier
Understanding mechanisms of ageing remains a complex challenge for biogerontologists,
but recent adaptations of evolutionary ageing theories offer a compelling lens in which to …

Evaluating endoplasmic reticulum stress and unfolded protein response through the lens of ecology and evolution

KN Yap, KL Yamada, S Zikeli, H Kiaris… - Biological …, 2021 - Wiley Online Library
Considerable progress has been made in understanding the physiological basis for
variation in the life‐history patterns of animals, particularly with regard to the roles of …

Ageing as “early-life inertia”: Disentangling life-history trade-offs along a lifetime of an individual

H Carlsson, E Ivimey-Cook, EML Duxbury… - Evolution …, 2021 - academic.oup.com
The theory that ageing evolves because of competitive resource allocation between the
soma and the germline has been challenged by studies showing that somatic maintenance …

Experimentally reduced insulin/IGF-1 signaling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring

MI Lind, S Ravindran, Z Sekajova, H Carlsson… - Evolution …, 2019 - academic.oup.com
Classical theory maintains that ageing evolves via energy trade-offs between reproduction
and survival leading to accumulation of unrepaired cellular damage with age. In contrast, the …