A quarter of a century after their advent, monoclonal antibodies have become the most
rapidly expanding class of pharmaceuticals for treating a wide variety of human diseases …

This article provides an overview of principles and barriers relevant to intracellular drug and
gene transport, accumulation and retention (collectively called as drug delivery) by means of …

Tumour pretargeting is a promising strategy for cancer diagnosis and therapy allowing for
the rational use of long circulating, highly specific monoclonal antibodies (mAbs) for both …

Radiolabeled monoclonal antibodies specific for tumor-associated antigens are used for the
diagnosis and therapy of malignant tumors. However, the blood clearance of antibodies is …

The relay delivery strategy is a two-step targeting approach based on two distinct modules in
which the first step with an initiator is to artificially create a target/environment which can be …

Therapeutic antibodies are well established as an important class of drugs in modern
medicine. The exquisite specificity and affinity for a specific target offered by antibodies has …

We are investigating the hypothesis that biotin multimers can be used with streptavidin and
monoclonal antibody conjugates in cancer pretargeting protocols to provide a method of …

Over the past several years, investigators in this laboratory and elsewhere have been
studying tumor localization by pretargeting with streptavidin and biotin or with avidin and …

Affibody molecules are small proteins engineered using a nonantibody scaffold.
Radiolabeled Affibody molecules are excellent imaging probes, but their application to …

Prostate-specific membrane antigen (PSMA) is a notable biomarker for diagnostic and
therapeutic applications in prostate cancer. Gold nanoparticles (AuNPs) provide an …