Brain feminization requires active repression of masculinization via DNA methylation

BM Nugent, CL Wright, AC Shetty, GE Hodes… - Nature …, 2015 - nature.com
The developing mammalian brain is destined for a female phenotype unless exposed to
gonadal hormones during a perinatal sensitive period. It has been assumed that the …

Of mice and rats: key species variations in the sexual differentiation of brain and behavior

PJ Bonthuis, KH Cox, BT Searcy, P Kumar… - Frontiers in …, 2010 - Elsevier
Mice and rats are important mammalian models in biomedical research. In contrast to other
biomedical fields, work on sexual differentiation of brain and behavior has traditionally …

Maintenance of sexual activity following androgen deprivation in males

CJ Duthie, HJ Calich, CM Rapsey, E Wibowo - Critical Reviews in …, 2020 - Elsevier
Androgen deprivation therapy (ADT) is a common treatment for men with systemic prostate
cancer. However, ADT leads to sexual dysfunction, causing> 80% of couples to cease …

Differential control of sex differences in estrogen receptor α in the bed nucleus of the stria terminalis and anteroventral periventricular nucleus

DA Kelly, MM Varnum, AA Krentzel, S Krug… - …, 2013 - academic.oup.com
The principal nucleus of the bed nucleus of the stria terminalis (BNSTp) and anteroventral
periventricular nucleus of the hypothalamus (AVPV) are sexually dimorphic, hormone …

Strain differences in post-castration sexual and aggressive behavior in male mice

CD David, BN Wyrosdic, JH Park - Behavioural Brain Research, 2022 - Elsevier
The degree to which male sexual behavior and territorial aggression are regulated by
gonadal steroid hormones depends strongly on species and experience. While castration …

Isoflurane preconditioning neuroprotection in experimental focal stroke is androgen-dependent in male mice

W Zhu, L Wang, L Zhang, JM Palmateer, NL Libal… - Neuroscience, 2010 - Elsevier
Isoflurane preconditioning neuroprotection in experimental stroke is male-specific. The role
of androgens in the ischemic sensitivity of isoflurane preconditioned male brain and whether …

Acquisition of sexual receptivity: roles of chromatin acetylation, estrogen receptor-α, and ovarian hormones

PJ Bonthuis, JK Patteson, EF Rissman - Endocrinology, 2011 - academic.oup.com
Sexually naïve, hormone-primed, C57BL/6J female mice are not receptive to mating
attempts by conspecific males. Repeated experience with sexually active males and …

X-chromosome dosage affects male sexual behavior

PJ Bonthuis, KH Cox, EF Rissman - Hormones and behavior, 2012 - Elsevier
Sex differences in the brain and behavior are primarily attributed to dichotomous androgen
exposure between males and females during neonatal development, as well as adult …

Neural growth hormone implicated in body weight sex differences

PJ Bonthuis, EF Rissman - Endocrinology, 2013 - academic.oup.com
As for many human diseases, the incidence of obesity and its associated health risks are
sexually dimorphic: worldwide the rate of obesity is higher in women. Sex differences in …

Evaluating the reproductive toxicology of tannery effluent in male SWISS mice

ATB Guimarães, R de Oliveira Ferreira… - Science of the total …, 2019 - Elsevier
The transformation of skin in-natura into leather in tannery industries generates large
volumes of organic matter that attract small mammals. ie, rodents living close to these …