Cellular senescence constitutes a stress response mechanism in reaction to a plethora of
stimuli. Senescent cells exhibit cell‐cycle arrest and altered function. While cell‐cycle …

Aging is inevitable. Along with reduced ability to maintain the homeostasis of various
biological processes, aging gradually deteriorates overall health. Extensive research on the …

Polygenic inheritance plays a pivotal role in driving multiple sclerosis susceptibility, an
inflammatory demyelinating disease of the CNS. We developed polygenic risk scores (PRS) …

Ageing represents the single biggest risk factor for development of neurodegenerative
disease. Despite being such long-lived cells, microglia have been relatively understudied for …

Oligodendrocyte progenitor cells (OPCs) play pivotal roles in myelin formation and
phagocytosis, communicating with neighboring cells and contributing to the integrity of the …

Within the central nervous system, ependymal cells form critical components of the blood-
cerebrospinal fluid barrier and the cerebrospinal fluid-brain barrier. These barriers provide …

Astrocytes, as the most abundant glial cells in the central nervous system, are tightly
integrated into neural networks and participate in numerous aspects of brain physiology and …

Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by
several pathological features, including selective neuronal loss, aggregation of specific …

Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a
smoldering inflammatory activity is present from the earliest stages of the disease and …

Neuroinflammatory diseases remain a therapeutic challenge, notably when progressing
towards neurodegeneration. In this context, multiple sclerosis represents a central nervous …