Accumulation of somatic mutations in the mitochondrial genome (mtDNA) has long been
proposed as a possible mechanism of mitochondrial and tissue dysfunction that occurs …

Ovarian cancer (OC) is the most lethal gynecologic tumor and is characterized by a high rate
of metastasis. Challenges in accurately delineating the metastatic pattern have greatly …

Time always leaves its mark, and our genome is no exception. Mutations in the genome of
somatic cells were first hypothesized to be the cause of aging in the 1950s, shortly after the …

The recognized importance of mutational spectra in molecular evolution is yet to be fully
exploited beyond human cancer studies and model organisms. The wealth of intraspecific …

Healthy human longevity is a global goal of the world health system. Determining the causes
and processes influencing human longevity is the primary fundamental goal facing the …

To elucidate the primary factors shaping mitochondrial DNA (mtDNA) mutagenesis, we
reconstructed a deep 192-component mtDNA mutational spectrum using 129,100 …

To elucidate the primary factors shaping mitochondrial DNA (mtDNA) mutagenesis, we
reconstructed a deep 192-component mtDNA mutational spectrum using 129,100 …

This short review provides basic knowledge on mitochondrial inheritance, its disorders, and
potential ways to overcome them in human reproductive medicine. The latter are currently …

Nucleotide sequence variability of whole mitochondrial genomes (mtDNA) was analyzed
and mutation spectra were reconstructed (by L-chain of mtDNA) in four regional groups of …

Using phylogenetic analysis of the nucleotide sequences of whole mitochondrial genomes
(mtDNA), the spectra of germline nucleotide substitutions (on the L-chain of mtDNA) were …