Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options
TJ Guzik, SA Mohiddin, A Dimarco, V Patel… - Cardiovascular …, 2020 - academic.oup.com
The novel coronavirus disease (COVID-19) outbreak, caused by SARS-CoV-2, represents
the greatest medical challenge in decades. We provide a comprehensive review of the …
the greatest medical challenge in decades. We provide a comprehensive review of the …
Hypertension, the renin–angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19: European Society of …
Systemic arterial hypertension (referred to as hypertension herein) is a major risk factor of
mortality worldwide, and its importance is further emphasized in the context of the novel …
mortality worldwide, and its importance is further emphasized in the context of the novel …
Pathophysiology of hypertension: the mosaic theory and beyond
DG Harrison, TM Coffman, CS Wilcox - Circulation research, 2021 - Am Heart Assoc
Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that
hypertension is the result of many factors that interact to raise blood pressure and cause end …
hypertension is the result of many factors that interact to raise blood pressure and cause end …
Obesity, hypertension, and cardiac dysfunction: novel roles of immunometabolism in macrophage activation and inflammation
AJ Mouton, X Li, ME Hall, JE Hall - Circulation research, 2020 - Am Heart Assoc
Obesity and hypertension, which often coexist, are major risk factors for heart failure and are
characterized by chronic, low-grade inflammation, which promotes adverse cardiac …
characterized by chronic, low-grade inflammation, which promotes adverse cardiac …
Immune mechanisms of hypertension
GR Drummond, A Vinh, TJ Guzik… - Nature Reviews …, 2019 - nature.com
Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …
Hypertension: do inflammation and immunity hold the key to solving this epidemic?
Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …
after normalization of blood pressure in patients with hypertension. Underlying immune cell …
Causal association between periodontitis and hypertension: evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal …
M Czesnikiewicz-Guzik, G Osmenda… - European heart …, 2019 - academic.oup.com
Aims Inflammation is an important driver of hypertension. Periodontitis is a chronic
inflammatory disease, which could provide a mechanism for pro-hypertensive immune …
inflammatory disease, which could provide a mechanism for pro-hypertensive immune …
Increased age, neutrophil-to-lymphocyte ratio (NLR) and white blood cells count are associated with higher COVID-19 mortality
Abstract Objective Coronavirus disease 19 (COVID-19) caused by the highly pathogenic
SARS-CoV-2, was first reported from Wuhan, China, in December 2019. The present study …
SARS-CoV-2, was first reported from Wuhan, China, in December 2019. The present study …
Obesity, kidney dysfunction, and inflammation: interactions in hypertension
JE Hall, AJ Mouton, AA da Silva… - Cardiovascular …, 2021 - academic.oup.com
Abstract Obesity contributes 65–75% of the risk for human primary (essential) hypertension
(HT) which is a major driver of cardiovascular and kidney diseases. Kidney dysfunction …
(HT) which is a major driver of cardiovascular and kidney diseases. Kidney dysfunction …