Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …

Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …

Importance Apolipoprotein E (APOE)* 2 andAPOE* 4 are, respectively, the strongest
protective and risk-increasing, common genetic variants for late-onset Alzheimer disease …

Dysregulation of lipid metabolism has emerged as a central component of many
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E …

Abstract Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for late-onset
Alzheimer's disease (LOAD), leading to earlier age of clinical onset and exacerbating …

Alzheimer's disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …

Dementia is more prevalent in Blacks than in Whites, likely due to a combination of
environmental and biological factors. Paradoxically, clinical studies suggest an attenuation …

A preponderance of evidence obtained from genetically modified mice and human
population studies reveals the association of apolipoprotein E (apoE) deficiency and …