Clinical and laboratory studies over recent decades have established branched evolution as
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …

Recent reports have demonstrated that oncogene amplification on extrachromosomal DNA
(ecDNA) is a frequent event in cancer, providing new momentum to explore a phenomenon …

The mechanisms behind the evolution of complex genomic amplifications in cancer have
remained largely unclear. Using whole-genome sequencing data of the pediatric tumor …

Human cells have twenty-three pairs of chromosomes. In cancer, however, genes can be
amplified in chromosomes or in circular extrachromosomal DNA (ecDNA), although the …

Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumor-promoting
genes and regulatory elements can free themselves from chromosomes and relocate to …

Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base
pairs, is independent of conventional chromosomes. Recently, eccDNAs have been …

Although the eukaryotic genome is mainly comprised of linear chromosomal DNA, genes
can also be found outside of chromosomes. The unconventional presence of …

Extrachromosomal circular DNA (eccDNA) is a type of double-stranded circular DNA that is
derived and free from chromosomes. It has a strong heterogeneity in sequence, length, and …

In cancer, complex genome rearrangements and other structural alterations, including the
amplification of oncogenes on circular extrachromosomal DNA (ecDNA) elements, drive the …

Extrachromosomal circular DNA was recently found to be particularly abundant in multiple
human cancer cells, although its frequency varies among different tumor types. Elevated …