Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …

An ongoing technological revolution is continually improving our ability to carry out very high-
resolution studies of gene expression patterns. Current technology enables the global gene …

Abstract The Zebrafish Information Network (zfin. org) is the central repository for Danio rerio
genetic and genomic data. The Zebrafish Information Network has served the zebrafish …

Reconstructing lineage relationships between cells within a tissue or organism is a long-
standing aim in biology. Traditionally, lineage tracing has been achieved through the …

Single-cell transcriptomic assays have enabled the de novo reconstruction of lineage
differentiation trajectories, along with the characterization of cellular heterogeneity and state …

In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …

The ability to define cell types and how they change during organogenesis is central to our
understanding of animal development and human disease. Despite the crucial nature of this …

Xenograft cell transplantation into immunodeficient mice has become the gold standard for
assessing pre-clinical efficacy of cancer drugs, yet direct visualization of single-cell …

We report on the quantitative proteomic analysis of single mammalian cells. Fluorescence‐
activated cell sorting was employed to deposit cells into a newly developed nanodroplet …

The classical roadmap of hematopoietic hierarchy has been proposed for nearly 20 years
and has become a dogma of stem cell research for most types of adult stem cells, including …