Regulatory T cells (Tregs) are essential to transplantation tolerance and their therapeutic
efficacy is well documented in animal models. Moreover, human Tregs can be identified …

T‐regulatory cells (Tregs) have a fundamental role in the establishment and maintenance of
peripheral tolerance. There is now compelling evidence that deficits in the numbers and/or …

A major challenge in transplantation medicine is controlling the very strong immune
responses to foreign antigens that are responsible for graft rejection. Although …

Regulatory T cells (Tregs) are long-lived cells that suppress immune responses in vivo in a
dominant and antigen-specific manner. Therefore, therapeutic application of Tregs to control …

The induction of graft tolerance remains the holy grail of transplantation. This is important as
chronic allograft dysfunction and the side effects of immunosuppression regimens place a …

With the advent of cellular therapies, it has become clear that the success of future therapies
in prolonging allograft survival will require an intimate understanding of the allorecognition …

The durable alloantibody responses that develop in organ transplant patients indicate long-
lived plasma cell output from T-dependent germinal centers (GCs), but which of the two …

In the 1970s, the capacity of Tcells to inhibit immunity and those from transplant tolerant
hosts to transfer alloantigenspecific suppression to lymphopenic recipients was described …

Solid organ transplantation is the standard treatment to improve both the quality of life and
survival in patients with various end-stage organ diseases. The primary barrier against …

The immune system mounts a response to non-self transplanted tissue through a number of
mechanisms. The indirect pathway of allorecognition, in which cells of the adaptive immune …