Abstract Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …

Colorectal cancer (CRC) is the third most frequently detected type of cancer, and the second
most common cause of cancer-related mortality globally. The American Cancer Society …

Abstract Elevated levels of Reactive Oxygen Species (ROS), increased antioxidant ability
and the maintenance of redox homeostasis can cumulatively contribute to tumor progression …

Cellular homeostasis plays a critical role in how an organism will develop and age.
Disruption of this fragile equilibrium is often associated with health degradation and …

Scope Butyrate (B) is a short‐chain fatty acid produced by dietary fiber, known to inhibit
histone deacetylases (HDACs) and possess cancer‐preventive/anticancer effects. However …

Simple Summary Transcription factor NRF2 controls expression of antioxidant and
detoxification genes. Normally, the activity of NRF2 is tightly controlled in the cell, and is …

Nuclear factor‐erythroid 2‐related factor 2 (Nrf2) is a transcriptional signaling pathway that
plays a crucial role in numerous clinical complications. Pivotal roles of Nrf2 have been …

Cancer is a borderless global health challenge that continues to threaten human health.
Studies have found that oxidative stress (OS) is often associated with the etiology of many …

Acute lung injury (ALI) is a syndrome caused by an excessive inflammatory response
characterized by intractable hypoxemia both inside and outside the lung, for which effective …

Baicalein is a natural flavonoid with various pharmacological activities including antitumor.
The synergistic anti-cancer effect of the combination of baicalein and Cisplatin (DDP) on …