L'évolution des peptides neuroendocriniens est souvent difficile à résoudre dans les
embranchements divergents à cause de duplications indépendantes dans différents …

The conformation of insulin in the crystalline state has been known for more than 30 years
but there remains uncertainty regarding the biologically active conformation and the …

Background The relaxin-like peptide family belongs in the insulin superfamily and consists
of 7 peptides of high structural but low sequence similarity; relaxin-1, 2 and 3, and the insulin …

This review describes some of the most typical features in the evolution of neuropeptides.
Neuropeptides are synthesized like other polypeptides and proteins, with an amino acid …

Despite sequence information from many vertebrates the evolution of the neuropeptide Y
(NPY) family of peptides has been difficult to resolve, particularly among ray-finned fishes …

Many chromosome regions in the human genome exist in four similar copies, suggesting
that the entire genome was duplicated twice in early vertebrate evolution, a concept called …

Neuropeptide Y (NPY) is a 36-amino-acid peptide that is widely and abundantly expressed
in the central nervous system of all vertebrates investigated. Related peptides have been …

The neuropeptide gonadotropin-releasing hormone (GnRH) plays an important role in the
control of reproductive functions. Vertebrates possess multiple GnRH isoforms that are …

Abstract I. Introduction 220 II. Proenkephalin 223 III. Prodynorphin 228 IV. Proorphanin 230
V. Proopiomelanocortin 233 VI. Post‐Translational Processing Mechanisms 236 VII. Origin …

The aims of the study were to outline the sequence of events that gave rise to the vertebrate
insulin-relaxin gene family and the chromosomal regions in which they reside. We analyzed …