trans-Cinnamaldehyde as a Novel Candidate to Overcome Bacterial Resistance: An Overview of In Vitro Studies

F Usai, A Di Sotto - Antibiotics, 2023 - mdpi.com
The increasing of drug-resistant bacteria and the scanty availability of novel effective
antibacterial agents represent alarming problems of the modern society, which stimulated …

Critical review on plant-derived quorum sensing signaling inhibitors in pseudomonas aeruginosa

K Vadakkan, K Sathishkumar, VO Mapranathukaran… - Bioorganic …, 2024 - Elsevier
Pseudomonas aeruginosa, a biofilm-forming organism with complex quorum mechanisms
(Las, Rhl, PQS, and IQS), poses an imminent danger to the healthcare sector and renders …

Design, green synthesis, and quorum sensing quenching potential of novel 2-oxo-pyridines containing a thiophene/furan scaffold and targeting a Las R gene on P …

YA Ammar, A Ragab, MA Migahed, S Al-Sharbasy… - RSC …, 2023 - pubs.rsc.org
The current trend in fighting bacteria is attacking the virulence and quorum-sensing (QS)
signals that control bacterial communication and virulence factors, especially biofilm …

Design of cinnamaldehyde-and gentamicin-loaded double-layer corneal nanofiber patches with antibiofilm and antimicrobial effects

S Cesur, E Ilhan, TA Tut, E Kaya, B Dalbayrak… - ACS …, 2023 - ACS Publications
In this study, two-layer poly (vinyl alcohol)/gelatin (PVA/GEL) nanofiber patches containing
cinnamaldehyde (CA) in the first layer and gentamicin (GEN) in the second layer were …

1H-Pyrrole-2, 5-dicarboxylic acid, a quorum sensing inhibitor from one endophytic fungus in Areca catechu L., acts as antibiotic accelerant against Pseudomonas …

J Liu, Z Wang, Y Zeng, W Wang, S Tang… - Frontiers in Cellular and …, 2024 - frontiersin.org
Pseudomonas aeruginosa has already been stipulated as a “critical” pathogen,
emphasizing the urgent need for researching and developing novel antibacterial agents due …

Repurposing carvacrol, cinnamaldehyde, and eugenol as potential anti-quorum sensing agents against uropathogenic Escherichia coli isolates in Alexandria, Egypt

HA Morgaan, HMG Omar, AS Zakaria, NM Mohamed - BMC microbiology, 2023 - Springer
Background Urinary tract infections represent one of the most frequent hospital and
community-acquired infections with uropathogenic Escherichia coli (UPEC) being the main …

α-Terpineol synergizes with gentamicin to rescue Caenorhabditis elegans from Pseudomonas aeruginosa infection by attenuating quorum sensing-regulated …

J Chadha, J Singh, K Harjai - Life Sciences, 2023 - Elsevier
Aims This study scrutinized α-Terpineol (α-T) for its anti-virulence and anti-fouling potential
against P. aeruginosa PAO1 in conjunction with gentamicin (GeN) using in-vitro, in-silico …

Repurposing albendazole as a potent inhibitor of quorum sensing-regulated virulence factors in Pseudomonas aeruginosa: Novel prospects of a classical drug

J Chadha, L Khullar, P Gulati, S Chhibber… - Microbial Pathogenesis, 2024 - Elsevier
Pseudomonas aeruginosa has emerged as a critical superbug that poses a serious threat to
public health. Owing to its virulence and multidrug resistance profiles, the pathogen …

Enhancing commercial antibiotics with trans-cinnamaldehyde in Gram-positive and Gram-negative bacteria: An in vitro approach

N Ferrando, MR Pino-Otín, D Ballestero, G Lorca… - Plants, 2024 - mdpi.com
One strategy to mitigate the emergence of bacterial resistance involves reducing antibiotic
doses by combining them with natural products, such as trans-cinnamaldehyde (CIN). The …

Synergism Between α-Terpineol and Terpinen-4-ol Potentiates Antivirulence Response Against Pseudomonas aeruginosa

J Chadha, G Moudgil, K Harjai - Indian Journal of Microbiology, 2024 - Springer
Antivirulence strategies have emerged as next-generation therapies that are now becoming
refractory to the use of traditional antimicrobial approaches. Considering the global medical …