Interactions between Borrelia burgdorferi and ticks

C Kurokawa, GE Lynn, JHF Pedra, U Pal… - Nature Reviews …, 2020 - nature.com
Borrelia burgdorferi is the causative agent of Lyme disease and is transmitted to vertebrate
hosts by Ixodes spp. ticks. The spirochaete relies heavily on its arthropod host for basic …

Lyme disease in humans

JD Radolf, K Strle, JE Lemieux, F Strle - Current issues in molecular …, 2021 - mdpi.com
Lyme disease (Lyme borreliosis) is a tick-borne, zoonosis of adults and children caused by
genospecies of the Borrelia burgdorferi sensu lato complex. The ailment, widespread …

mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent

A Sajid, J Matias, G Arora, C Kurokawa… - Science translational …, 2021 - science.org
Ixodes scapularis ticks transmit many pathogens that cause human disease, including
Borrelia burgdorferi. Acquired resistance to I. scapularis due to repeated tick exposure has …

The essential role of tick salivary glands and saliva in tick feeding and pathogen transmission

L Šimo, M Kazimirova, J Richardson… - Frontiers in cellular and …, 2017 - frontiersin.org
As long-term pool feeders, ticks have developed myriad strategies to remain discreetly but
solidly attached to their hosts for the duration of their blood meal. The critical biological …

Tick salivary compounds: their role in modulation of host defences and pathogen transmission

M Kazimírová, I Štibrániová - Frontiers in cellular and infection …, 2013 - frontiersin.org
Ticks require blood meal to complete development and reproduction. Multifunctional tick
salivary glands play a pivotal role in tick feeding and transmission of pathogens. Tick …

Ticks and tick-borne infections: complex ecology, agents, and host interactions

SK Wikel - Veterinary Sciences, 2018 - mdpi.com
Ticks transmit the most diverse array of infectious agents of any arthropod vector. Both ticks
and the microbes they transmit are recognized as significant threats to human and veterinary …

The Lyme disease agent exploits a tick protein to infect the mammalian host

N Ramamoorthi, S Narasimhan, U Pal, F Bao, XF Yang… - Nature, 2005 - nature.com
Abstract The Lyme disease agent, Borrelia burgdorferi, is maintained in a tick–mouse cycle,.
Here we show that B. burgdorferi usurps a tick salivary protein, Salp15 (ref.), to facilitate the …

A clear and present danger: tick-borne diseases in Europe

P Heyman, C Cochez, A Hofhuis… - Expert review of anti …, 2010 - Taylor & Francis
Ticks can transmit a variety of viruses, bacteria or parasites that can cause serious infections
or conditions in humans and animals. While tick-borne diseases are becoming an …

Biology of infection with Borrelia burgdorferi

K Tilly, PA Rosa, PE Stewart - Infectious disease clinics of North America, 2008 - Elsevier
The spirochete Borrelia burgdorferi is a tick-borne obligate parasite whose normal reservoir
is a variety of small mammals. Although infection of these natural hosts does not lead to …

C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity

U Švajger, M Anderluh, M Jeras, N Obermajer - Cellular signalling, 2010 - Elsevier
The dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-
SIGN) is a type II C-type lectin whose expression is restricted to the most potent antigen …