Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …

Osteoporosis is metabolic bone disease caused by an altered balance between bone
anabolism and catabolism. This dysregulated balance is responsible for fragile bones that …

Danio rerio (zebrafish) is an elective model organism for the study of vertebrate
development because of its high degree of homology with human genes and organs …

In 2019, the Nosology Committee of the International Skeletal Dysplasia Society provided an
updated version of the Nosology and Classification of Genetic Skeletal Disorders. This is a …

Discovery of genotype–phenotype relationships remains a major challenge in clinical
medicine. Here, we combined three sources of phenotypic data to uncover a new …

Research on the genetic mechanisms underlying human skeletal development and disease
have largely relied on studies in mice. However, recently the zebrafish has emerged as a …

CATSHL syndrome, characterized by camptodactyly, tall stature and hearing loss, is caused
by loss-of-function mutations of fibroblast growth factor receptors 3 (FGFR3) gene. Most …

Collagens are the most abundant vertebrate extracellular matrix proteins. They form a
superfamily of 28 members that show a remarkable diversity in molecular and …

Bone disorders affect millions of people worldwide and treatments currently available often
produce undesirable secondary effects or have limited efficacy. It is therefore of the utmost …

Fish skeletal development has long been correlated with nutritional factors. Lack of zebrafish
nutritional standardization, especially during the early stages, decreases the reproducibility …