Systemic iron homeostasis needs to be tightly controlled, as both deficiency and excess iron
cause major global health concerns, such as iron deficiency anemia, hemochromatosis, etc …

The 5′ UTRs of mRNAs are critical for translation regulation during development, but their
in vivo regulatory features are poorly characterized. Here, we report the regulatory …

Erythropoiesis is a complex, precise, and lifelong process that is essential for maintaining
normal body functions. Its strict regulation is necessary to prevent a variety of blood …

This study aimed to uncover novel genes associated with neurodevelopmental disorders
(NDD) by leveraging recent large-scale de novo burden analysis studies to enhance a …

Glucose plays a key role in shaping pancreatic β cell function. Thus, deciphering the
mechanisms by which this nutrient stimulates β cells holds therapeutic promise for …

Alanyl-transfer RNA synthetase 2 (AARS2) is a nuclear encoded mitochondrial tRNA
synthetase that is responsible for charging of tRNA-Ala with alanine during mitochondrial …

The RNA-binding protein Pcbp2 is widely expressed in the innate and adaptive immune
systems and is essential for mouse development. To determine whether Pcbp2 is required …

Oct4 is a commonly known marker of pluripotent stem cells as well as one of the key factors
required for pluripotency induction. Its gene (Pou5f1) is subject to complicated regulation …

Congenital heart disease (CHD) is the most common birth defect affecting> 1.35 million
newborn babies worldwide. CHD can lead to prenatal, neonatal, postnatal lethality or life …

Abstract Background and Aims: Hepatocellular carcinoma (HCC), a prevalent solid organ
malignancy, is intricately linked to the glycolytic enzyme Alpha-enolase (ENO1). ENO1's …