An overview of Nrf2 signaling pathway and its role in inflammation
Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …
Alzheimer's disease, and many others, and the current state of available drugs prompted …
Transcriptional regulation by Nrf2
Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
[HTML][HTML] Antioxidant response elements: Discovery, classes, regulation and potential applications
Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …
Bone marrow mesenchymal stem cells support acute myeloid leukemia bioenergetics and enhance antioxidant defense and escape from chemotherapy
D Forte, M García-Fernández, A Sanchez-Aguilera… - Cell metabolism, 2020 - cell.com
Like normal hematopoietic stem cells, leukemic stem cells depend on their bone marrow
(BM) microenvironment for survival, but the underlying mechanisms remain largely …
(BM) microenvironment for survival, but the underlying mechanisms remain largely …
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …
LE Tebay, H Robertson, ST Durant, SR Vitale… - Free Radical Biology …, 2015 - Elsevier
Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …
inducible expression of a battery of genes encoding key components of the glutathione …
[HTML][HTML] The emerging role of Nrf2 in mitochondrial function
AT Dinkova-Kostova, AY Abramov - Free Radical Biology and Medicine, 2015 - Elsevier
The transcription factor NF-E2 p45-related factor 2 (Nrf2; gene name NFE2L2) allows
adaptation and survival under conditions of stress by regulating the gene expression of …
adaptation and survival under conditions of stress by regulating the gene expression of …
A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis
Necrotic cell death during Mycobacterium tuberculosis (Mtb) infection is considered host
detrimental since it facilitates mycobacterial spread. Ferroptosis is a type of regulated …
detrimental since it facilitates mycobacterial spread. Ferroptosis is a type of regulated …
Klotho deficiency causes heart aging via impairing the Nrf2-GR pathway
Rationale: Cardiac aging is an important contributing factor for heart failure, which affects a
large population but remains poorly understood. Objective: The purpose of this study is to …
large population but remains poorly understood. Objective: The purpose of this study is to …
Achieving life through death: redox biology of lipid peroxidation in ferroptosis
H Bayır, TS Anthonymuthu, YY Tyurina, SJ Patel… - Cell chemical …, 2020 - cell.com
Redox balance is essential for normal brain, hence dis-coordinated oxidative reactions
leading to neuronal death, including programs of regulated death, are commonly viewed as …
leading to neuronal death, including programs of regulated death, are commonly viewed as …
The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities
J Lewerenz, SJ Hewett, Y Huang… - Antioxidants & redox …, 2013 - liebertpub.com
The antiporter system xc− imports the amino acid cystine, the oxidized form of cysteine, into
cells with a 1: 1 counter-transport of glutamate. It is composed of a light chain, xCT, and a …
cells with a 1: 1 counter-transport of glutamate. It is composed of a light chain, xCT, and a …