Mitochondria are structurally and functionally distinct organelles that produce adenosine
triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to …

Epithelial cells line the lumen of tubular organs and are key players in their respective
functions. They establish a unique luminal environment by providing a protective barrier and …

STUDY QUESTION Are epididymosomes implicated in protein transfer from the epididymis
to spermatozoa? SUMMARY ANSWER We characterized the contribution of epididymal …

Spermatozoa released from the testis are unable to fertilize an egg without a coordinated
process of maturation in the lumen of the epididymis. Relatively little is known about the …

CFTR (cystic fibrosis transmembrane conductance regulator) is a tightly regulated anion
channel that mediates chloride and bicarbonate conductance in many epithelia and in other …

Introduction One of the most intriguing aspects of male reproductive physiology is the ability
of the epididymis to prevent the mounting of immune responses against the onslaught of …

Male infertility is a heterogeneous condition of largely unknown etiology that affects at least
7% of men worldwide. Classical genetic approaches and emerging next-generation …

In mammals, sperm cells produced within the testis are structurally differentiated but remain
immotile and are unable to fertilize the oocyte unless they undergo a series of maturation …

Occludin (OCLN) is a tight junction protein and Ocln deletion mutation causes male infertility
in mice. However, the role of OCLN in male reproductive system remains unknown. In this …

Abstract Epididymal Cysteine Rich Secretory Proteins 1 and 4 (CRISP1 and CRISP4)
associate with sperm during maturation and play different roles in fertilization. However …