The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

Glycine is one of the most important inhibitory neurotransmitters in the spinal cord and the
brainstem, and glycinergic synapses have a well-established role in the regulation of …

Volatile anaesthetics have historically been considered to act in a nonspecific manner on
the central nervous system,. More recent studies, however, have revealed that the receptors …

Urethane is widely used as an anesthetic for animal studies because of its minimal effects
on cardiovascular and respiratory systems and maintenance of spinal reflexes. Despite its …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

The molecular mechanisms of general anaesthetics have remained largely obscure since
their introduction into clinical practice just over 150 years ago. This review describes the …

There is substantial evidence that GABAergic neurotransmission is important for many
behavioral actions of ethanol and there are reports spanning more than 30 years of literature …

Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in
synaptic function are prominent among these effects. Acute exposure to EtOH activates or …

Transmitter-gated ion channels mediate rapid synaptic transmission in the CNS and
constitute important targets for many neuroactive drugs. Inhibitory glycine receptors (GlyRs) …

Fifteen percent to 35% of the United States population experiences tinnitus, a subjective
“ringing in the ears”. Up to 10% of those afflicted report severe and disabling symptoms …