Colicins are proteins produced by and toxic for some strains of Escherichia coli. They are
produced by strains of E. coli carrying a colicinogenic plasmid that bears the genetic …

Homing endonucleases are encoded by open reading frames that are embedded within
group I, group II and archael introns, as well as inteins (intervening sequences that are …

The CRISPR-associated protein Cas9 is an RNA-guided DNA endonuclease that uses RNA–
DNA complementarity to identify target sites for sequence-specific double-stranded DNA …

The Snf2 family of helicase-related proteins includes the catalytic subunits of ATP-
dependent chromatin remodelling complexes found in all eukaryotes. These act to regulate …

Two classes of nucleases degrade the cellular DNA during apoptosis. Cell-autonomous
nucleases cleave DNA within the dying cell. They are not essential for apoptotic cell death or …

The present invention relates to a method for the generation of compact Transcription
Activator-Like Effector Nucleases (TALENs) that can efficiently target and process double …

Nucleotidyl-transfer enzymes, which synthesize, degrade and rearrange DNA and RNA,
often depend on metal ions for catalysis. All DNA and RNA polymerases, MutH-like or …

The structure of I-HmuI, which represents the last family of homing endonucleases without a
defining crystallographic structure, has been determined in complex with its DNA target. A …

Group II intron-encoded proteins (IEPs) have both reverse transcriptase (RT) activity, which
functions in intron mobility, and maturase activity, which promotes RNA splicing by …

It is more than 80 years since Gratia first described 'a remarkable antagonism between two
strains of Escherichia coli'. Shown subsequently to be due to the action of proteins (or …