A recent flurry of reports correlates replication timing (RT) with mutation rates during both
evolution and cancer. Specifically, point mutations and copy number losses correlate with …

In the event of a radiological or nuclear accident, or when physical dosimetry is not
available, the scoring of radiation-induced chromosomal aberrations in lymphocytes …

Biological effects of high-LET (linear energy transfer) radiation have received increasing
attention, particularly in the context of more efficient radiotherapy and space exploration …

Microgravity and space radiation (SR) are two highly influential factors affecting humans in
space flight (SF). Many health problems reported by astronauts derive from endothelial …

DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are
a potential source of genome instability and chromosome translocation. TOP2-induced DNA …

The formation and spatial arrangement of chromosome territories (CTs) in interphase has
been posited to influence the outcome and frequency of genomic translocations. This is …

Centromeres of Candida albicans form on unique and different DNA sequences but a
closely related species, Candida tropicalis, possesses homogenized inverted repeat (HIR) …

High linear energy transfer (LET) α particles are important with respect to the carcinogenic
risk associated with human exposure to ionizing radiation, most notably to radon and its …

The importance of higher order nuclear structure and compartmentalization for the control of
the cell life is now indisputable. The genome of higher eukaryotes is organized into definite …

Biological monitoring of radiation exposure relies heavily on the quantification of
chromosome aberrations such as dicentrics and reciprocal translocations in the peripheral …