Mitochondria are essential in most eukaryotes and are involved in numerous biological
functions including ATP production, cofactor biosyntheses, apoptosis, lipid synthesis, and …

Introduction: Mitochondria are cellular organelles that perform numerous bioenergetic,
biosynthetic, and regulatory functions and play a central role in iron metabolism …

Work during the past 14 years has shown that mitochondria are the primary site for the
biosynthesis of iron–sulfur (Fe/S) clusters. In fact, it is this process that renders mitochondria …

Iron–sulfur (Fe/S) clusters belong to the most ancient protein cofactors in life, and fulfill
functions in electron transport, enzyme catalysis, homeostatic regulation, and sulfur …

Lipoate is a covalently bound cofactor essential for five redox reactions in humans: in four 2-
oxoacid dehydrogenases and the glycine cleavage system (GCS). Two enzymes are from …

Abstract Iron–sulfur (Fe–S) clusters are ancient, ubiquitous cofactors composed of iron and
inorganic sulfur. The combination of the chemical reactivity of iron and sulfur, together with …

Abstract Iron–sulphur (Fe–S) clusters are inorganic cofactors that are found in nearly all
species and are composed of various combinations of iron and sulphur atoms. Fe–S clusters …

Mitochondria and fatty acids are tightly connected to a multiplicity of cellular processes that
go far beyond mitochondrial fatty acid metabolism. In line with this view, there is hardly any …

The essential process of iron-sulfur (Fe/S) cluster assembly (ISC) in mitochondria occurs in
three major phases. First,[2Fe-2S] clusters are synthesized on the scaffold protein ISCU2; …

Iron sulfur (Fe-S) clusters, preassembled on the ISCU scaffold, are transferred to target
proteins or to intermediate scaffolds by a dedicated chaperone-cochaperone system …