The basic body plan of the mammalian embryo is established through gastrulation, a pivotal
early postimplantation event during which the three major germ layers (endoderm …

Recent discoveries in stem cell and developmental biology have introduced a new era
marked by the generation of in vitro models that recapitulate early mammalian development …

One week after fertilization, human embryos implant into the uterus. This event requires the
embryo to form a blastocyst consisting of a sphere encircling a cavity lodging the embryo …

The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation …

Naive human pluripotent stem cells have the remarkable ability to self-organize into
blastocyst-like structures (" blastoids") that model lineage segregation in the pre …

Understanding human development is of fundamental biological and clinical importance.
Despite its significance, mechanisms behind human embryogenesis remain largely …

Recently, several studies using cultures of human embryos together with single-cell RNA-
seq analyses have revealed differences between humans and mice, necessitating the study …

Recent advances in human blastoids have opened new avenues for modeling early human
development and implantation. One limitation of our first protocol for human blastoid …

The recent derivation of human trophoblast stem cells (TSCs) from placental
cytotrophoblasts and blastocysts opened opportunities for studying the development and …

Primordial germ cells (PGCs) are the embryonic precursors of sperm and eggs. They
transmit genetic and epigenetic information across generations. Given the prominent role of …