Highlights•New therapeutic strategies are moving towards nanomedicine and the use of
innovative drug delivery systems to release drugs within the joint.•Ethical considerations …

Zebrafish (Danio rerio) are aquatic vertebrates with significant homology to their terrestrial
counterparts. While zebrafish have a centuries-long track record in developmental and …

SOX8 was linked in a genome-wide association study to human height heritability, but roles
in chondrocytes for this close relative of the master chondrogenic transcription factor SOX9 …

The biological characteristics of the temporomandibular joint disc involve complex cellular
network in cell identity and extracellular matrix composition to modulate jaw function. The …

Abnormal subchondral bone remodeling leading to sclerosis is a main feature of
osteoarthritis (OA), and osteomodulin (OMD), a proteoglycan involved in extracellular matrix …

After traumatic injury, healing of mammalian ligaments is typically associated with fibrotic
scarring as opposed to scar-free regeneration. In contrast, here we show that the ligament …

The evolution of a unique craniofacial complex in vertebrates made possible new ways of
breathing, eating, communicating and sensing the environment. The head and face develop …

Adult vertebrate cartilage is usually quiescent. Some vertebrates possess ocular scleral
skeletons composed of cartilage or bone. The morphological characteristics of the spotted …

Humans and other jawed vertebrates rely heavily on their craniofacial skeleton for eating,
breathing, and communicating. As such, it is vital that the elements of the craniofacial …

Objective: Cartilage, as the majority of adult mammalian tissues, has limited regeneration
capacity. Cartilage degradation consecutive to joint injury or aging then leads to irreversible …