Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as
cellular sensors to detect energy availability and modulate metabolic processes. Two …

Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have
traditionally been linked with calorie restriction and aging in mammals. These proteins also …

NAD is a vital molecule in all organisms. It is a key component of both energy and signal
transduction—processes that undergo crucial changes in cancer cells. NAD+-dependent …

In diverse organisms, calorie restriction slows the pace of ageing and increases maximum
lifespan. In the budding yeast Saccharomyces cerevisia e, calorie restriction extends …

Recognition of pathogens by innate and adaptive immune cells instructs rapid alterations of
cellular processes to promote effective resolution of infection. To accommodate increased …

The Sir2 deacetylase modulates organismal life-span in various species. However, the
molecular mechanisms by which Sir2 increases longevity are largely unknown. We show …

Homeostatic mechanisms in mammals respond to hormones and nutrients to maintain blood
glucose levels within a narrow range. Caloric restriction causes many changes in glucose …

DNA damage-induced acetylation of p53 protein leads to its activation and either growth
arrest or apoptosis. We show here that the protein product of the gene hSIR2 SIRT1, the …