Abstract In tumors, Cancer-Associated Fibroblasts (CAFs) constitute the most prominent
component of the tumor microenvironment (TME). CAFs are heterogeneous and composed …

The roles of cancer‐associated fibroblasts (CAF) in the progression of various types of
cancers are well established. CAF promote cancer progression through pleiotropic …

Abstract Background Squamous cell carcinoma (SqCC) is a subtype of non-small cell lung
cancer for which patient prognosis remains poor. The extracellular matrix (ECM) is critical in …

Abstract Cancer-Associated Fibroblasts (CAFs) represent the most prominent component of
the tumor microenvironment (TME). Recent studies demonstrated that CAF are …

Cancers are complex ecosystems composed of malignant cells embedded in an intricate
microenvironment made of different non-transformed cell types and extracellular matrix …

Alterations in the tumor microenvironment are closely associated with the metabolic
phenotype of tumor cells. Cancer-associated fibroblasts (CAFs) play a pivotal role in tumor …

Abstract Background Cancer-associated fibroblasts (CAFs) are molecularly heterogeneous
mesenchymal cells that interact with malignant cells and immune cells and confer anti-and …

Non-small cell lung cancer (NSCLC) constitutes the majority of lung cancer, which is the
leading cause of cancer-related deaths in the world. Nearly 70% of NSCLC patients were …

Large cell carcinoma (LCC) is a rare and aggressive lung cancer subtype with poor
prognosis and no targeted therapies. Tumor-associated fibroblasts (TAFs) derived from LCC …

Fibroblasts synthesise the extracellular matrix (ECM) such as collagen and elastin, the
excessive accumulation of which can lead to fibrosis and organ dysfunction under …