Cellular senescence and inflammaging in the skin microenvironment

YI Lee, S Choi, WS Roh, JH Lee, TG Kim - International journal of …, 2021 - mdpi.com
Cellular senescence and aging result in a reduced ability to manage persistent types of
inflammation. Thus, the chronic low-level inflammation associated with aging phenotype is …

[HTML][HTML] Inflammaging and the Skin

SM Pilkington, S Bulfone-Paus, CEM Griffiths… - Journal of Investigative …, 2021 - Elsevier
As global life expectancy continues to rise, we are challenged with maintaining health into
old age. One strategy is to target the chronic low-level inflammation associated with aging …

New insights into the pathogenesis of bullous pemphigoid: 2019 update

G Genovese, G Di Zenzo, E Cozzani, E Berti… - Frontiers in …, 2019 - frontiersin.org
There are several lines of evidence indicating that the physiopathological bases of bullous
pemphigoid (BP), the most common subepidermal autoimmune bullous disease, are …

The role of T cells in pemphigus vulgaris and bullous pemphigoid

H Fang, Q Li, G Wang - Autoimmunity Reviews, 2020 - Elsevier
Pemphigus vulgaris (PV) and bullous pemphigoid (BP) are autoantibody-mediated diseases
clinically characterized by blisters and erosions of skin and/or mucous membranes. Immune …

Targeting lymphoid-derived IL-17 signaling to delay skin aging

P Solá, E Mereu, J Bonjoch, M Casado-Peláez, N Prats… - Nature Aging, 2023 - nature.com
Skin aging is characterized by structural and functional changes that contribute to age-
associated frailty. This probably depends on synergy between alterations in the local niche …

Current clinical trials in pemphigus and pemphigoid

K Izumi, K Bieber, RJ Ludwig - Frontiers in Immunology, 2019 - frontiersin.org
Autoimmune bullous dermatoses (AIBDs) are a group of rare chronic inflammatory skin
diseases, which clinically manifest as blisters and erosions of the skin and/or mucosa …

Staphylococcus aureus proteases trigger eosinophil-mediated skin inflammation

SN Kline, NA Orlando, AJ Lee, MJ Wu… - Proceedings of the …, 2024 - National Acad Sciences
Staphylococcus aureus skin colonization and eosinophil infiltration are associated with
many inflammatory skin disorders, including atopic dermatitis, bullous pemphigoid …

Autoimmune bullous skin diseases, pemphigus and pemphigoid

S Egami, J Yamagami, M Amagai - Journal of Allergy and Clinical …, 2020 - Elsevier
Autoimmune bullous skin diseases, such as pemphigus and pemphigoid, may enable
clarification of the mechanisms of immune regulation in the skin. Pemphigus and …

[HTML][HTML] Pemphigus and pemphigoid: from disease mechanisms to druggable pathways

CT Ellebrecht, D Maseda, AS Payne - Journal of Investigative Dermatology, 2022 - Elsevier
Pemphigus and pemphigoid are paradigms for understanding the mechanisms of antibody-
mediated autoimmune disease in humans. In pemphigus, IgG4-predominant autoantibodies …

The cytokine milieu of bullous pemphigoid: Current and novel therapeutic targets

R Maglie, F Solimani, D Didona, C Pipitò… - Frontiers in …, 2023 - frontiersin.org
Bullous pemphigoid (BP) is the most common autoimmune bullous disease, characterized
by severe pruritus and skin blistering. The loss of tolerance against Collagen XVII, also …