Molecular mechanisms of neuroinflammation in aging and Alzheimer's disease progression

FL Andronie-Cioara, AI Ardelean… - International journal of …, 2023 - mdpi.com
Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …

Physical exercise and health: a focus on its protective role in neurodegenerative diseases

R Bonanni, I Cariati, U Tarantino… - Journal of functional …, 2022 - mdpi.com
Scientific evidence has demonstrated the power of physical exercise in the prevention and
treatment of numerous chronic and/or age-related diseases, such as musculoskeletal …

The potential role of cytokines and growth factors in the pathogenesis of Alzheimer's disease

G Ogunmokun, S Dewanjee, P Chakraborty… - Cells, 2021 - mdpi.com
Alzheimer's disease (AD) is one of the most prominent neurodegenerative diseases, which
impairs cognitive function in afflicted individuals. AD results in gradual decay of neuronal …

Overview of the blood biomarkers in Alzheimer's disease: promises and challenges

C Delaby, C Hirtz, S Lehmann - Revue Neurologique, 2023 - Elsevier
The increasing number of people with advanced Alzheimer's disease (AD) represents a
significant psychological and financial cost to the world population. Accurate detection of the …

Therapeutic potential of neurotrophic factors in Alzheimer's Disease

A Nasrolahi, F Javaherforooshzadeh… - Molecular biology …, 2022 - Springer
Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the
most common cause of dementia among the elderly population. AD is accompanied with the …

Amyloidogenesis and Neurotrophic Dysfunction in Alzheimer's Disease: Do They have a Common Regulating Pathway?

F Jiao, D Jiang, Y Li, J Mei, Q Wang, X Li - Cells, 2022 - mdpi.com
The amyloid cascade hypothesis has predominately been used to describe the
pathogenesis of Alzheimer's disease (AD) for decades, as Aβ oligomers are thought to be …

The significance of glial cell line-derived neurotrophic factor analysis in Progressive Supranuclear Palsy

P Alster, D Otto-Ślusarczyk, S Szlufik… - Scientific Reports, 2024 - nature.com
Abstract Progressive Supranuclear Palsy (PSP) is an atypical parkinsonism. Major subtypes
of the disease: PSP-Richardson's Syndrome (PSP-RS) and PSP Parkinsonism Predominant …

Blunt dopamine transmission due to decreased GDNF in the PFC evokes cognitive impairment in Parkinson's disease

CX Tang, J Chen, KQ Shao, YH Liu… - Neural Regeneration …, 2023 - journals.lww.com
Studies have found that the absence of glial cell line-derived neurotrophic factor may be the
primary risk factor for Parkinson's disease. However, there have not been any studies …

The conspicuous link between ear, brain and heart–could neurotrophin-treatment of age-related hearing loss help prevent alzheimer's disease and associated …

S Shityakov, K Hayashi, S Störk, V Scheper, T Lenarz… - Biomolecules, 2021 - mdpi.com
Alzheimer's disease (AD), the most common cause of dementia in the elderly, is a
neurodegenerative disorder associated with neurovascular dysfunction and cognitive …

Aging-related protein alterations in the brain

RA Syed, M Hayat, H Qaiser, M Uzair… - Journal of …, 2024 - content.iospress.com
Aging is an intrinsic aspect of an organism's life cycle and is characterized by progressive
physiological decline and increased susceptibility to mortality. Many age-associated …